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Unlock Multiplayer Features
For every two Host Collectibles that you find in the single player game, you will unlock an extra feature for the multiplayer mode in the order shown below:

Office Multiplayer Level
Storage Multiplayer Level
Raimi and Rabbit Characters
Medical Multiplayer Level
Towel Girl and Bat Characters
Helipad Multiplayer Level
Chef and Rat Characters
Raid Multiplayer Level
Dead Garden Multiplayer Level
Summit Multiplayer Level
Volks and Roach Characters
Complex Multiplayer Level
Heaven Multiplayer Level
Boss Multiplayer Level
Anna and Imp Characters
Catacombs Level

Fatal Bug
During Level 8 Rourke, after you’ve taken possession of Rourke, head to the Command Station. (After you’ve gotten off the elevator, head down the hall. The Command Center is the door in front of you, and a guard should be on your left guarding another hallway; he escorts you to your new armor.) As you enter the Command Center, look at nearly any computer with a blue screen (there are 7 of them, 3 are actually working). Seem familiar? It should. Examine the screen and it will say “The operating system has crashed on this computer.” This, of course, is referring to Microsoft Windows and the Blue Screen of Death, and Nintendo’s little stab at Microsoft.

Escaping from ghosts
This trick requires a controller with an auto-fire feature. Set the auto-fire to a button. Every time you get caught by them, just hold a button. This helps when fighting the Boss that takes over Rouqe's body.

Prototype weapons
At the part were you scare the three scientists, the one you possess determines which weapon you will get. To get one of them, have a host knock on the door.

Base: Rocket launcher
To get the rocket launcher on the multi-player map "Base", jump boost to get on the skinny platform where a man is standing. Go left from the gun turret to get there.

Metroid reference
Look in one of the lockers in the girl's shower room to find Samus' helmet.

Hidden Gamecube
Look in one of the lockers in the girl's shower room to find a Gamecube.

Weird dialogue
Talk to the guard that took you to get Rouqe's armor. Once you get the armor he will say nothing for a short while, then say "What am I doing here?"

Multi-player bonuses
Collect the following number of Host Collectibles during single player mode to unlock the corresponding multi-player bonus.